What is the safety factor used by the EPA when setting tolerances?

The safety factor used by the EPA when setting tolerances is often 100 times lower than the No Observed Effect Level (NOEL). This is implemented as a precautionary measure to ensure that there is a substantial margin of safety for all population groups, including sensitive subgroups such as children and pregnant women. By using this factor, the agency aims to account for any uncertainties in the data regarding the toxicity of a pesticide and its potential effects on human health and the environment. This practice reflects the EPA's commitment to protecting public health while also recognizing the variability in responses to pesticides among different individuals. The other factors mentioned in the choices represent lower safety margins, which do not provide the same level of protection and thoroughness as the 100-times reduction.